Epilepsy After Febrile Seizures: Twins Suggest Genetic Influence
نویسندگان
چکیده
منابع مشابه
Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis.
Experimental prolonged febrile seizures (FS) lead to structural and molecular changes that promote hippocampal hyperexcitability and reduce seizure threshold to further convulsants. However, whether these seizures provoke later-onset epilepsy, as has been suspected in humans, has remained unclear. Previously, intermittent EEGs with behavioural observations for motor seizures failed to demonstra...
متن کاملMelatonin’s Effect in Febrile Seizures and Epilepsy
OBJECTIVE Recognition of risk factors for febrile seizures (FS) and epilepsy is essential. Studies regarding the role of melatonin in these convulsive disorders are limited. This study determines the relationship between serum melatonin levels and FS and epilepsy in children. MATERIALS & METHODS A population of 111 children with simple FS, complex FS, and epilepsy (37 children per group, resp...
متن کاملVagus nerve stimulation for genetic epilepsy with febrile seizures plus (GEFS+) accompanying seizures with impaired consciousness
Genetic epilepsy with febrile seizures plus (GEFS+) is characterized by childhood-onset epilepsy syndrome. It involves febrile seizures and a variety of afebrile epileptic seizure types within the same pedigree with autosomal-dominant inheritance. Approximately 10% of individuals with GEFS+ harbor SCN1A, a gene mutation in one of the voltage-gated sodium channel subunits. Considerably less comm...
متن کاملGeneralized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes.
The clinical and genetic relationships of febrile seizures and the generalized epilepsies are poorly understood. We ascertained a family with genealogical information in 2000 individuals where there was an unusual concentration of individuals with febrile seizures and generalized epilepsy in one part of the pedigree. We first clarified complex consanguineous relationships in earlier generations...
متن کاملAxon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus.
Febrile seizures are a common childhood seizure disorder and a defining feature of genetic epilepsy with febrile seizures plus (GEFS+), a syndrome frequently associated with Na+ channel mutations. Here, we describe the creation of a knockin mouse heterozygous for the C121W mutation of the beta1 Na+ channel accessory subunit seen in patients with GEFS+. Heterozygous mice with increased core temp...
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ژورنال
عنوان ژورنال: Pediatric Neurology
سال: 2016
ISSN: 0887-8994
DOI: 10.1016/j.pediatrneurol.2015.10.008